Meharvan "Sonny" Singh, PhD, Chairman and Professor of the Pharmacology and Neuroscience Department at UNT Health Science Center, and his team recently received a five-year program project grant from the National Institutes of Health to continue their research that explores the biological basis for a finite "window of opportunity" for estrogen and progesterone treatment to benefit the brain.
Through the studies proposed in this $5.8 million grant, Singh's team of scientists will identify some of the cellular and molecular machinery that is required for estrogen and progesterone to benefit the brain. Then the researchers intend to define how these cellular and molecular components of the brain expand the "therapeutic window" and help ensure that the hormones don't have negative effects on brain function.
Results could lead to safer and more effective therapeutic strategies for treating menopause and reducing the risk for various brain disorders (including Alzheimer's disease) that increases during the post-menopausal period.
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